Get the expert guidance you need to offer your patients the best possible outcomes with Hematology: Basic Principles and Practice, 7th Edition. This thoroughly up-to-date text contains both unparalleled scientific content and must-know clinical guidance, so you can enhance your problem-solving skills and make optimal use of the newest diagnostic techniques and therapeutic options in this fast-changing field.Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas.Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more.Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies.New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device.Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
Table of Contents:
1.Anatomy and Physiology of the Gene2.Epigenetics and Epigenomics3.Genomic Approaches to Hematology4.Regulation of Gene Expression, Transcription, Splicing and RNA Metabolism5.Protein Synthesis, Processing, and Trafficking6.Protein Architecture: Relationship of Form and Function7.Signaling Transduction and Metabolomics8.Pharmacogenomics and Hematologic Diseases9.Hematopoietic Stem Cell Biology10.Stem Cell Model of Hematologic Malignancies11.Hematopoietic Microenvironment12.Cell Adhesion13.Hematopoietic Cell Trafficking and Chemokines14.Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization15.Vascular Growth in Health and Disease16.Cytokine/Receptor families and signal transduction17.Control of Cell Division18.Cell Death19.Overview and Compartmentalization of the Immune System20.B-Cell Development21.T-Cell Immunity22.Natural Killer Cell Immunity23.Dendritic Cell Biology24.Complement and Immunoglobulin biology leading to clinical translation25.Tolerance and Autoimmunity26.Biology of Erythropoiesis, Erythroid Differentiation, and Maturation27.Granulocytopiesis and Monocytopoiesis28.Thrombocytopoiesis29.Inherited Forms of Bone Marrow Failure30.Aplastic Anemia31.Paroxysmal Nocturnal Hemoglobinuria32.Acquired Disorders of Unilineage Blood Cell Production33.Pathobiology of the Human Erythrocyte and Its Hemoglobins
34.Approach to Anemia in the Adult and Child35.Pathophysiology of Iron Homeostasis36.Disorders of Iron Metabolism: Iron Deficiency and Overload37.Anemia of Chronic Diseases38.Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias39.Megaloblastic Anemias40.Thalassemia Syndromes41.Pathobiology of Sickle Cell Disease42.Sickle Cell Disease: Clinical Features and Management43.Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias44.Red Blood Cell Enzymopathies45.Red Blood Cell Membrane Disorders46.Autoimmune Hemolytic Anemia47.Extrinsic Nonimmune Hemolytic Anemias48.Granulocytosis, Granulocytopenia, Monocytosis, and Monocytopenia49.Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia50.Disorders of Phagocyte Function51.Congenital Disorders of Lymphocyte Function52.Histiocytic Disorders53.Lysosomal Storage Diseases: Perspectives and Principles54.Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases55.Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications56.The CytoGenomic Basis of Hematological Malignancies57.Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies58.Pathobiology of Acute Myeloid Leukemia59.Clinical Manifestations and Treatment of Acute Myeloid Leukemia60.Myelodysplastic Syndromes: Biology and Treatment61.Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults62.Acute Myeloid Leukemia in Children63.Myelodysplastic Syndrome and Myeloproliferative Syndrome in Children64.Pathobiology of Acute Lymphoblastic Leukemia65.Clinical Manifestations and Treatment in Children of Acute Lymphoblastic Leukemia66.Acute Lymphocytic Leukemia in Adults67.Chronic Myeloid Leukemia68.The Polycythemias69.Essential Thrombocythemia70.Primary Myelofibrosis71.Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes72.Mast Cells and Systemic Mastocytosis73.The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas74.Origins of Hodgkin Disease75.Hodgkin Lymphoma: Clinical Manifestations, Staging, and Therapy76.Origins of Non-Hodgkin Lymphomas77.Chronic Lymphocytic Leukemia78.Hairy Cell Leukemia79.Clinical Manifestations and Treatment of Indolent Lymphomas: Marginal Zone Lymphomas (Extranodal/Malt, Splenic, and Nodal)80.Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma81.Mantle Cell Lymphoma82.Diagnosis and Treatment of Diffuse Large B-Cell Lymphoma (DLBCL) and Burkitt Lymphoma (BL)83.Viral-Related Lymphomas84.Malignant Lymphomas in Childhood85.T-Cell Lymphomas86.Multiple Myeloma87.Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma88.Immunoglobuin Light-Chain Amyloidosis (Primary Amyloidosis)89.Clinical Approach to Infections in the Compromised Host90.Psychosocial Aspects of Hematologic Disorders91.Pain Management and Antiemetic Therapy in Hematologic Disorders92.Palliative Care93.Late Complications of Hematologic Diseases and Their Therapies94.Overview and Historical Perspective of Current Cell-Based Therapies95.Practical Aspects of Hematologic Stem Cell Harvesting and Mobilization96.IND Enabling Processes for Cell-Based Therapies97.Graft Engineering and Cell Processing98.Principles of Cell-Based Genetic Therapies99.Mesenchymal Stromal Cells100.T Cell Therapy of Hematological Diseases101.NK Cell-Based Therapies102.Immune Checkpoint Blockade in Hematologic Malignancies103.Overview and Choice of Donor of Hematopoietic Stem Cell Transplantation104.Indications and Outcomes of Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults105.Unrelated Donor Hematopoietic Cell Transplantation106.Haploidentical Hematopoietic Cell Transplantation107.Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies108.Graft-versus-Host Disease and Graft-versus-Leukemia Responses: Biology and Therapy109.Complications after Hematopoietic Cell Transplantation110.Human Blood Group Antigens and Antibodies111.Principles of Red Blood Cell Transfusion112.Clinical Considerations in Platelet Transfusion Therapy113.Human Leukocyte Antigen and Human Neutrophil Antigen Systems114.Principles of Neutrophil (Granulocyte) Transfusions115.Transfusion of Plasma Derivatives: Plasma, Cryoprecipitate, Albumin, and Immunoglobulins116.Preparation of Plasma-Derived and Recombinant Human Plasma Proteins117.Transfusion Therapy for Coagulation Factor Deficiencies118.Hemapheresis119.Transfusion Reactions to Blood and Cell Therapy Products120.Transfusion-Transmitted Diseases121.Pediatric Transfusion Medicine122.Overview of Hemostasis and Thrombosis123.The Blood Vessel Wall124.Megakaryocyte and Platelet Structure125.Molecular Basis of Platelet Function126.Molecular Basis of Blood Coagulation127.Regulatory Mechanisms in Hemostasis128.Clinical Approach to the Patient with Bleeding or Bruising129.Laboratory Evaluation of Hemostatic and Thrombotic Disorders130.Acquired Disorders of Platelet Function131.Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura132.Thrombocytopenia Caused by Platelet Destruction, Hypersplenism, or Hemodilution133.Heparin-Induced Thrombocytopenia134.Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndromes135.Hemophilia A and B136.Inhibitors in Hemophilia A and B137.Rare Coagulation Factor Deficiencies138.Structure, Biology, and Genetics of Von Willebrand Factor139.Disseminated Intravascular Coagulation140.Hypercoagulable States141.The Antiphospholipid Syndrome142.Venous Thromboembolism143.Mechanical Interventions in Arterial and Venous Thrombosis144.Atherothrombosis145.Stroke146.Acute Coronary Syndromes147.Atrial Fibrillation148.Peripheral Artery Disease149.Antithrombotic Drugs150.Disorders of Coagulation in the Neonate151.Hematologic Changes of Pregnancy152.Hematologic Manifestations of Childhood Illness153.Hematologic Manifestations of Systemic Disease: Liver Disease154.Hematologic Manifestations of Systemic Disease: Renal Disease155.Hematologic Manifestations of Cancer156.Integrated Therapies in Patients with Hematologic Diseases157.Hematologic Manifestations of AIDS158.Hematologic Manifestations of Parasitic Diseases159.Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis160.The Spleen and Its Disorders161.Hematology in Aging162 Resources for the Hematologist