The landmark text that has guided generations of hematologists and related practitioners―updated with the latest research findings and improved format and presentation
Doody’s Core Titles for 2021!
Long revered for its comprehensiveness and extraordinary depth of detail, Williams Hematology provides essential coverage of the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood and marrow cells and coagulation proteins. The text contains a wealth of basic science and translational pathophysiology for optimal, lifelong learning. Experts in research and clinical hematology, the editors are known worldwide for their contributions to the field.
This new edition contains everything that has made Williams Hematology the go-to resource for decades and has been updated with new chapters and critical new research into the molecular mechanisms responsible for hematological disorders and the impact on diagnosis and treatment. And the new format enables you to access each chapter via content modules covering key topics, with summaries, infographics, and cases―all linked to review questions for self-assessment. The full-color presentation integrates images of blood and tissue findings where they are cited in the text.
NEW TO THIS EDITION:
Immune Cell Therapy Dendritic Cell and Natural Killer Cell Therapy
The processes of cell death and survival
Application of Big Data and Deep Learning in Hematology
Contents: فهرست فصول
CoverTitle PageCopyright PageContentsContributorsPrefacePART I Clinical Evaluation of the Patient1. Initial Approach to the Patient: History and Physical Examination2. Examination of Blood and Marrow Cells3. Consultative HematologyPART II The Organization of the Lymphohematopoietic Tissues4. Structure of the Marrow and the Hematopoietic Microenvironment5. The Organization and Structure of Lymphoid TissuesPART III Epochal Hematology6. Hematology of the Fetus and Newborn7. Hematology During Pregnancy8. Hematology in Older PersonsPART IV Molecular and Cellular Hematology9. Genetic Principles and Molecular Biology10. Genomics and Epigenomics11. Cytogenetic and Genetic Abnormalities12. Application of Big Data and Deep Learning in Hematology13. Metabolism of Hematologic Neoplastic Cells14. Cell Death15. Cell-Cycle Regulation and Hematologic Disorders16. Signal Transduction Pathways17. Hematopoietic Stem Cells, Progenitors, and Cytokines18. The Inflammatory Response19. Innate Immunity20. The Biology of Innate Lymphoid Cells and Natural Killer Cells21. Dendritic Cells and Adaptive ImmunityPART V Therapeutic Principles22. Immune Checkpoint Inhibitors23. Immune Cell Therapy: Chimeric Antigen Receptor T-Cell Therapy24. Immune Cell Therapy: Dendritic Cell and Natural Killer Cell Therapy25. Vaccine Therapy26. Gene Therapy for Hematologic Diseases27. Regenerative Medicine: Induced Pluripotent Stem Cells and Blood Cell Engineering28. Pharmacology and Toxicity of Antineoplastic Drugs29. Hematopoietic Stem Cell Transplantation30. Therapeutic Apheresis: Indications, Efficacy, and Complications31. Treatment of Infections in the Immunocompromised Host32. Antithrombotic TherapyPART VI The Erythrocyte33. Structure and Composition of the Erythrocyte34. Erythropoiesis and Red Cell Turnover35. Clinical Manifestations and Classification of Erythrocyte Disorders36. Aplastic Anemia: Acquired and Inherited37. Pure Red Cell Aplasia38. Anemia of Chronic Disease39. Erythropoietic Effects of Endocrine Disorders40. The Hereditary Dyserythropoietic Anemias41. Paroxysmal Nocturnal Hemoglobinuria42. Folate, Cobalamin, and Megaloblastic Anemias43. Iron Metabolism44. Iron Deficiency and Overload45. Anemia Resulting from Other Nutritional Deficiencies46. Anemia Associated with Marrow Infiltration47. Erythrocyte Membrane Disorders48. Erythrocyte Enzyme Disorders49. Thalassemia: A Disorder of Globin Synthesis50. Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities51. Methemoglobinemia and Other Dyshemoglobinemias52. Fragmentation Hemolytic Anemia53. Erythrocyte Disorders as a Result of Toxic Agents54. Hemolytic Anemia Resulting from Infections with Microorganisms55. Hemolytic Anemia Resulting from Immune Injury56. Alloimmune Hemolytic Disease of the Fetus and Newborn57. Hypersplenism and Hyposplenism58. Primary and Secondary Erythrocytoses/Polycythemias59. The Porphyrias60. Polyclonal and Hereditary Sideroblastic AnemiasPART VII Neutrophils, Eosinophils, Basophils, and Mast Cells61. Structure and Composition of Neutrophils, Eosinophils, and Basophils62. Classification and Clinical Manifestations of Neutrophil Disorders63. Neutropenia and Neutrophilia64. Disorders of Neutrophil Function65. Eosinophils and Their Disorders66. Basophils and Mast Cells and Their DisordersPART VIII Monocytes and Macrophages67. Structure, Receptors, and Functions of Monocytes and Macrophages68. Production, Distribution, and Activation of Monocytes and Macrophages69. Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages70. Monocytosis and Monocytopenia71. Inflammatory and Malignant Histiocytosis72. Gaucher Disease and Related Lysosomal Storage DiseasesPART IX Lymphocytes and Plasma Cells73. The Structure of Lymphocytes and Plasma Cells74. Lymphopoiesis75. Functions of B Lymphocytes and Plasma Cells In Immunoglobulin Production76. Functions of T Lymphocytes: T-Cell Receptors for Antigen77. Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders78. Lymphocytosis and Lymphocytopenia79. Immunodeficiency Diseases80. Hematologic Manifestations of Human Immunodeficiency Virus and the Acquired Immunodeficiency Syndrome81. Mononucleosis SyndromesPART X Malignant Myeloid Diseases82. Classification and Clinical Manifestations of the Clonal Myeloid Disorders83. Polycythemia Vera84. Essential Thrombocythemia85. Primary Myelofibrosis86. Myelodysplastic Syndromes87. Acute Myelogenous Leukemia88. Chronic Myelogenous Leukemia and Related DisordersPART XI Malignant Lymphoid Diseases89. Classification of Malignant Lymphoid Disorders90. Acute Lymphoblastic Leukemia91. Chronic Lymphocytic Leukemia92. Hairy Cell Leukemia93. Large Granular Lymphocytic Leukemia94. General Considerations of Lymphomas: Incidence Rates, Etiology, Diagnosis, Staging, and Primary Extranodal Disease95. Pathology of Lymphomas96. Hodgkin Lymphoma97. Diffuse Large B-Cell Lymphoma and Related Diseases98. Follicular Lymphoma99. Mantle Cell Lymphoma100. Marginal Zone B-Cell Lymphomas101. Burkitt Lymphoma102. Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sézary Syndrome)103. Mature T-Cell and Natural Killer Cell Lymphomas104. Plasma Cell Neoplasms: General Considerations105. Essential Monoclonal Gammopathy106. Myeloma107. Immunoglobulin Light Chain Amyloidosis108. Macroglobulinemia109. Heavy-Chain DiseasePART XII Hemostasis and Thrombosis110. Megakaryopoiesis and Thrombopoiesis111. Platelet Morphology, Biochemistry, and Function112. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis113. Control of Coagulation Reactions114. Vascular Function in Hemostasis115. Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis116. Thrombocytopenia117. Heparin-Induced Thrombocytopenia118. Hereditary and Reactive Thrombocytosis119. Inherited Platelet Disorders120. Acquired Qualitative Platelet Disorders121. The Vascular Purpuras122. Hemophilia A and Hemophilia B123. Inherited Deficiencies of Coagulation Factors II, V, V+VIII, VII, X, XI, and XIII124. Hereditary Fibrinogen Abnormalities125. von Willebrand Disease126. Antibody-Mediated Coagulation Factor Deficiencies127. Disseminated Intravascular Coagulation128. Thrombotic Microangiopathies129. Hemolytic Uremic Syndrome130. Hemostatic Alterations in Liver Diseases and Liver Transplantation131. Hereditary Thrombophilia132. The Antiphospholipid Syndrome133. Venous Thrombosis134. Atherothrombosis: Disease Initiation, Progression, and Treatment135. Fibrinolysis and ThrombolysisPART XIII Transfusion Medicine136. Erythrocyte Antigens and Antibodies137. Human Leukocyte and Platelet Antigens138. Blood Procurement and Red Cell Transfusion139. Preservation and Clinical Use of Platelets140. Using Plasma and Plasma Component TherapyAcronyms and AbbreviationsIndex