Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .vii
Section I: Molecular Biology and Biochemistry
Chapter 1:Nucleic Acid Structure and Organization . . . . . . . . . . . . . . . . .3
Chapter 2:DNA Replication and Repair . . . . . . . . . . . . . . . . . . . . . . . . . . . .17
Chapter 3:Transcription and RNA Processing . . . . . . . . . . . . . . . . . . . . . .33
Chapter 4: The Genetic Code, Mutations, and Translation . . . . . . . . . . . .49
Chapter 5: Regulation of Eukaryotic Gene Expression . . . . . . . . . . . . . . .73
Chapter 6: Genetic Strategies in Therapeutics . . . . . . . . . . . . . . . . . . . . . .83
Chapter 7: Techniques of Genetic Analysis . . . . . . . . . . . . . . . . . . . . . . . .99
Chapter 8: Amino Acids, Proteins, and Enzymes . . . . . . . . . . . . . . . . . . .115
Chapter 9: Hormones . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .131
Chapter 10:Vitamins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .145
Chapter 11:Overview of Energy Metabolism . . . . . . . . . . . . . . . . . . . . .159
Chapter 12:Glycolysis and Pyruvate Dehydrogenase . . . . . . . . . . . . . .169
Chapter 13: Citric Acid Cycle and Oxidative Phosphorylation . . . . . . . .187
Chapter 14: Glycogen, Gluconeogenesis, and the HexoseMonophosphate Shunt . . . . . . . . . . . . . . . . . . . . . . . . . . . . .199
Chapter 15:Lipid Synthesis and Storage . . . . . . . . . . . . . . . . . . . . . . . . . .217
Chapter 16:Lipid Mobilization and Catabolism . . . . . . . . . . . . . . . . . . .239
Chapter 17: Amino Acid Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . .261
Chapter 18:Purine and Pyrimidine Metabolism . . . . . . . . . . . . . . . . . . .287
Section II: Medical Genetics
Chapter 1: Single-Gene Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .303
Chapter 2: Population Genetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .333
Chapter 3: Cytogenetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .347
Chapter 4: Genetics of Common Diseases . . . . . . . . . . . . . . . . . . . . . . . .371
Chapter 5: Recombination Frequency . . . . . . . . . . . . . . . . . . . . . . . . . . .379
Chapter 6: Genetic Diagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .389
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .405
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