Genetics: Analysis and Principles is a one-semester, introductory genetics textbook that takes an experimental approach to understanding genetics. By weaving one or two experiments into the narrative of each chapter, students can simultaneously explore the scientific method and understand the genetic principles that have been learned from these experiments. The pedagogy of Genetics: Analysis & Principles has been designed to foster student learning. Instead of being a collection of facts and figures,this text is intended to be an engaging and motivating textbook in which formative assessment allows students to move ahead and learn the material in a productive way.
Contents: فهرست فصول
Title PageCopyright PageBrief ContentsContentsAbout The AuthorDedicationPrefaceConnect PagePart I IntroductionChapter 1 Overview of Genetics1.1 The Molecular Expression of Genes1.2 The Relationship Between Genes and Traits1.3 Fields of Genetics1.4 The Science of GeneticsPart II Patterns of InheritanceChapter 2 Mendelian Inheritance2.1 Mendel’s Study of Pea Plants2.2 Law of Segregation2.3 Law of Independent Assortment2.4 Studying Inheritance Patterns in Humans2.5 Probability and StatisticsChapter 3 Chromosome Transmission During Cell Division and Sexual Reproduction3.1 General Features of Chromosomes3.2 Cell Division3.3 Mitosis and Cytokinesis3.4 Meiosis3.5 Sexual Reproduction3.6 The Chromosome Theory of Inheritance and Sex ChromosomesChapter 4 Extensions of Mendelian Inheritance4.1 Overview of Simple Inheritance Patterns4.2 Dominant and Recessive Alleles4.3 Environmental Effects on Gene Expression4.4 Incomplete Dominance, Overdominance, and Codominance4.5 Genes on Sex Chromosomes4.6 Sex-Influenced and Sex-Limited Inheritance4.7 Lethal Alleles4.8 Understanding Complex Phenotypes Caused by Mutations in Single Genes4.9 Gene InteractionsChapter 5 Non-Mendelian Inheritance5.1 Maternal Effect5.2 Epigenetics: Dosage Compensation5.3 Epigenetics: Genomic Imprinting5.4 Extranuclear InheritanceChapter 6 Genetic Linkage and Mapping in Eukaryotes6.1 Overview of Linkage6.2 Relationship Between Linkage and Crossing Over6.3 Genetic Mapping in Plants and Animals6.4 Genetic Mapping in Haploid Eukaryotes6.5 Mitotic RecombinationChapter 7 Genetic Transfer and Mapping in Bacteria7.1 Overview of Genetic Transfer in Bacteria7.2 Bacterial Conjugation7.3 Conjugation and Mapping via Hfr Strains7.4 Bacterial Transduction7.5 Bacterial Transformation7.6 Medical Relevance of Horizontal Gene TransferChapter 8 Variation in Chromosome Structure and Number8.1 Microscopic Examination of Eukaryotic Chromosomes8.2 Changes in Chromosome Structure: An Overview8.3 Deletions and Duplications8.4 Inversions and Translocations8.5 Changes in Chromosome Number: An Overview8.6 Variation in the Number of Chromosomes Within a Set: Aneuploidy8.7 Variation in the Number of Sets of Chromosomes8.8 Natural and Experimental Mechanisms That Produce Variation in Chromosome NumberPart III Molecular Structure AND Replication of the Genetic MaterialChapter 9 Molecular Structure of DNA and RNA9.1 Identification of DNA as the Genetic Material9.2 Overview of DNA and RNA Structure9.3 Nucleotide Structure9.4 Structure of a DNA Strand9.5 Discovery of the Double Helix9.6 Structure of the DNA Double Helix9.7 RNA StructureChapter 10 Molecular Structure of Chromosomes and Transposable elements10.1 Organization of Functional Sites Along Bacterial Chromosomes10.2 Structure of Bacterial Chromosomes10.3 Organization of Functional Sites Along Eukaryotic Chromosomes10.4 Sizes of Eukaryotic Genomes and Repetitive Sequences10.5 Transposition10.6 Structure of Eukaryotic Chromosomes in Nondividing Cells10.7 Structure of Eukaryotic Chromosomes During Cell DivisionChapter 11 DNA Replication11.1 Structural Overview of DNA Replication11.2 Bacterial DNA Replication: The Formation of Two Replication Forks at the Origin of Replication11.3 Bacterial DNA Replication: Synthesis of New DNA Strands11.4 Bacterial DNA Replication: Chemistry and Accuracy11.5 Eukaryotic DNA ReplicationPart IV Molecular Properties of GenesChapter 12 Gene Transcription and RNA Modification12.1 Overview of Transcription12.2 Transcription in Bacteria12.3 Transcription in Eukaryotes12.4 RNA Modification12.5 A Comparison of Transcription and RNA Modification in Bacteria and EukaryotesChapter 13 Translation of mRNA13.1 The Genetic Basis for Protein Synthesis13.2 The Relationship Between the Genetic Code and Protein Synthesis13.3 Experimental Determination of the Genetic Code13.4 Structure and Function of tRNA13.5 Ribosome Structure and Assembly13.6 Stages of TranslationChapter 14 Gene Regulation in Bacteria14.1 Overview of Transcriptional Regulation14.2 Regulation of the lac Operon14.3 Regulation of the trp Operon14.4 Translational and Posttranslational Regulation14.5 RiboswitchesChapter 15 Gene Regulation in Eukaryotes I: Transcriptional AND TRANSLATIONAL Regulation15.1 Regulatory Transcription Factors15.2 Chromatin Remodeling, Histone Variants, and Histone Modification15.3 DNA Methylation15.4 The ENCODE Project15.5 Regulation of TranslationChapter 16 Gene Regulation in Eukaryotes II: Epigenetics16.1 Overview of Epigenetics16.2 Heterochromatin: Function, Formation, Structure, and Maintenance16.3 Epigenetics and Development16.4 Paramutation16.5 Epigenetics and Environmental AgentsChapter 17 Non-coding RNAs17.1 Overview of Non-coding RNAs17.2 Non-coding RNAs: Effects on Chromatin Structure and Transcription17.3 Non-coding RNAs: Effects on Translation, mRNA Degradation, and RNA Modifications17.4 Non-coding RNAs and Protein Targeting17.5 Non-coding RNAs and Genome Defense17.6 Role of Non-coding RNAs in Human DiseasesChapter 18 Genetics of Viruses18.1 Virus Structure and Genetic Composition18.2 Overview of Viral Reproductive Cycles18.3 Bacteriophage Reproductive Cycle18.4 HIV Reproductive CycleChapter 19 Gene Mutation, DNA Repair, and Recombination19.1 Effects of Mutations on Gene Structure and Function19.2 Random Nature of Mutations19.3 Spontaneous Mutations19.4 Induced Mutations19.5 DNA Repair19.6 Homologous RecombinationPart V Genetic TechnologiesChapter 20 MOLECULAR Technologies20.1 Gene Cloning Using Vectors20.2 Polymerase Chain Reaction20.3 DNA Sequencing20.4 Gene Editing20.5 Blotting Methods to Detect Gene Products20.6 Methods for Analyzing DNA- and RNA-Binding ProteinsChapter 21 Biotechnology21.1 Uses of Microorganisms in Biotechnology21.2 Genetically Modified Animals21.3 Reproductive Cloning and Stem Cells21.4 Genetically Modified PlantsChapter 22 Genomics I: Analysis of DNA22.1 Overview of Chromosome Mapping22.2 Cytogenetic Mapping via Microscopy22.3 Linkage Mapping via Crosses22.4 Physical Mapping via Cloning and DNA Sequencing22.5 Genome-Sequencing Projects22.6 MetagenomicsChapter 23 Genomics II: Functional Genomics, Proteomics, and Bioinformatics23.1 Functional Genomics23.2 Proteomics23.3 BioinformaticsPart VI Genetic Analysis of Individuals and PopulationsChapter 24 Medical Genetics24.1 Inheritance Patterns of Genetic Diseases24.2 Detection of Disease-Causing Alleles via Haplotypes24.3 Genetic Testing and Screening24.4 Prions24.5 Human Gene Therapy24.6 Personalized MedicineChapter 25 Genetic Basis of Cancer25.1 Overview of Cancer25.2 Oncogenes25.3 Tumor-Suppressor Genes25.4 Role of Epigenetics in CancerChapter 26 Developmental genetics26.1 Overview of Animal Development26.2 Invertebrate Development26.3 Vertebrate Development26.4 Plant Development26.5 Sex Determination in AnimalsChapter 27 Population Genetics27.1 Genes in Populations and the Hardy-Weinberg Equation27.2 Overview of Microevolution27.3 Natural Selection27.4 Genetic Drift27.5 Migration27.6 Nonrandom Mating27.7 Sources of New Genetic VariationChapter 28 COMPLEX AND Quantitative TRAITS28.1 Overview of Complex and Quantitative Traits28.2 Statistical Methods for Evaluating Quantitative Traits28.3 Polygenic Inheritance28.4 Identification of Genes That Control Quantitative Traits28.5 Heritability28.6 Selective BreedingChapter 29 Evolutionary Genetics29.1 Origin of Species29.2 Phylogenetic Trees29.3 Molecular EvolutionGlossaryAppendix AAppendix BIndex