Clinical Biochemistry Lecture Notes presents the fundamental science behind common biochemical investigations used in clinical practice. Taking a system-based approach, it explores the underlying physiological rationale for tests, with each test explained within the context of disruption by disease. It also explores the value and limitations of biochemical investigations, while helping readers to quickly develop the knowledge and skills required to select the appropriate investigations for diagnosis and management, and to correctly interpret test results. Case studies throughout chapters place the information within a clinical context to further assist readers in the development of test-selection and interpretation skills.
Key features include:
Now in its tenth edition, this classic introductory, reference, and revision text is indispensable to medical students, and all those who want to quickly acquire a practical understanding of the scientific principles underpinning biochemical tests and a working knowledge of test selection, test procedures, and the interpretation of results within a clinical context.
Contents: فهرست فصول
CoverTitle PagePrefaceList of abbreviationsAbout the companion website1 Requesting and interpreting testsIntroductionCollection of specimensThe use of clinical biochemistry testsPoint of care testing (POCT)Interpretation of clinical biochemistry testsSources of variation in test resultsClinical audit in laboratory medicineFURTHER READING2 Disturbances of water, sodium and potassium balanceIntroductionWater and sodium balancePotassium balanceFluid and electrolyte balance in surgical patientsIntravenous fluid administrationFURTHER READING3 Acid–base balance and oxygen transportIntroductionTransport of carbon dioxideRenal mechanisms for reabsorption and H excretionBuffering of hydrogen ionsInvestigating acid–base balanceDisturbances ofacid–base statusInterpretation of results of acid–base assessmentOther investigations in acid–base assessmentTreatment of acid–base disturbancesOxygen transportIndications for full blood acid–base and oxygen measurementsRespiratory insufficiencyOxygen therapyFURTHER READING4 Renal diseaseIntroductionImpaired renal functionTests of glomerular functionTests of tubular functionRenal handling of sodium and potassiumAcute kidney injuryChronic kidney diseaseProteinuriaRenal stonesFURTHER READING5 Disorders of calcium, phosphate and magnesium metabolismCalcium homeostasisHypercalcaemiaHypocalcaemiaMetabolic bone diseasePhosphate metabolismMagnesium metabolism6 Diabetes mellitus and hypoglycaemiaGlucose homeostasisDiabetes mellitusHypoglycaemiaFURTHER READING7 Disorders of the hypothalamus and pituitaryIntroductionThe hypothalamusAnterior pituitary hormonesEndocrine changes in anorexia nervosaAnterior pituitary disease and its investigationPosterior pituitary hormones8 Abnormalities of thyroid functionIntroductionThyroid hormone synthesis, action and metabolismInvestigations to determine thyroid statusInterpreting results of thyroid function testsThyroid cancerMiscellaneous tests and thyroid disease9 Disorders of the adrenal cortex and medullaIntroductionRegulation of adrenal steroid hormone synthesis and secretionInvestigation of suspected adrenocortical hyperfunctionInvestigation of suspected adrenocortical insufficiencyBiochemical tests in the investigation of hypertensionPhaeochromocytoma10 Investigation of gonadal function infertility, menstrual irregularities and hirsutismIntroductionMale gonadal functionInvestigation of infertility and male hypogonadismFemale gonadal function11 Pregnancy and antenatal screeningIntroductionThe foetoplacental unitEffect of pregnancy on biochemical testsComplications in pregnancyPre‐natal diagnosis of foetal abnormalitiesFURTHER READING12 Cardiovascular disordersThe diagnosis of myocardial infarctionThe diagnosis of heart failureThe diagnosis of thromboembolic diseaseCardiovascular risk factorsMetabolism of plasma lipoproteinsInvestigation of plasma lipid abnormalitiesOther biochemical cardiovascular risk factors or markersCalculation of cardiovascular risk and its treatment by lipid loweringFURTHER READING13 Liver diseaseIntroductionStructure of the liverLiver function testsThe place of biochemical tests in the diagnosis of liver disease14 Gastrointestinal tract diseaseIntroductionStomachThe pancreasSmall intestine and colonThe investigation of malabsorption and diarrhoeaFURTHER READING15 NutritionIntroductionPrincipal dietary constituentsAssessment of nutritional statusNutritional supportMajor nutritional problemsFURTHER READING16 Inflammation, immunity and paraproteinaemiaIntroductionChanges in plasma proteins in trauma, infection and inflammation – ‘the acute‐phase response’The immunoglobulins and disease17 Malignancy and tumour markersIntroductionTumour markers commonly used in clinical practice18 Disorders of iron and porphyrin metabolismIntroductionIron metabolismPorphyrin metabolismAbnormal derivatives of haemoglobin19 Uric acid, gout and purine metabolismIntroductionPurine metabolism and uric acidSerum urateHyperuricaemiaHypouricaemiaFURTHER READING20 Central nervous system and cerebrospinal fluidIntroductionCSF compositionExamination of CSFFURTHER READING21 Therapeutic drug monitoring and chemical toxicologyIntroductionTherapeutic drug monitoring (TDM)Acute poisoningIndustrial and occupational hazardsFURTHER READING22 Clinical biochemistry in paediatrics and the elderlyIntroductionPaediatricsInherited metabolic disordersThe elderlyIndexEnd User License Agreement