The perfect balance of theory and practice! Here’s the must-have information you need to understand the essential principles of immunology and to master the serology techniques most commonly used in the laboratory. Easy-to-read, student-friendly coverage focuses on the direct application of theory to clinical laboratory practice, preparing you for the real world in which you will practice. The 4th Edition of this popular text has been completely updated and revised throughout to reflect the latest advances in the field. A brand-new full-color layout makes the content easier to understand than ever before. An access code inside new printed texts unlocks a wealth of learning tools online at DavisPlus, including a Davis Digital eBook, review questions, and laboratory exercises that make learning and studying easier. See what students and instructors are saying about previous editions… “I just LOVE this book. This book is written WELL! Short chapters and VERY compact!”― Nadezeda Shcherbakova, Student “Great book. Very easy to use.”― Cheryl L Barela, Student “I love the way the book is organized.”―Wendy Miller, MS, CLS(NSA), MT(ASCP)SI “I enthusiastically support the author’s approach…I think this is a very valuable text…”―Stephen M. Johnson, MS, MT (ASCP).
Contents: فهرست فصول
SECTION I: Nature of the Immune System1 Introduction to Immunity and the Immune SystemImmunity and ImmunizationInnate Versus Adaptive ImmunityCells of the Innate Immune SystemCells of the Adaptive Immune SystemOrgans of the Immune System2 Nature of Antigens and the Major Histocompatibility ComplexFactors Influencing the Immune ResponseTraits of ImmunogensEpitopesHaptensAdjuvantsRelationship of Antigens to the HostMajor Histocompatibility Complex3 Innate ImmunityExternal Defense SystemInternal Defense System4 Adaptive ImmunityT-Cell DifferentiationStages in B-Cell DifferentiationThe Role of T Cells in the Adaptive Immune ResponseThe Role of B Cells in the Adaptive Immune ResponseLaboratory Identification of Lymphocytes5 Antibody Structure and FunctionTetrapeptide Structure of ImmunoglobulinsThe Nature of Light ChainsHeavy-Chain SequencingHinge RegionThree-Dimensional Structure of AntibodiesTheories to Explain Antibody DiversityGenes Coding for ImmunoglobulinsMonoclonal Antibody6 CytokinesIntroduction to CytokinesCytokines in the Innate Immune ResponseCytokines in the Adaptive Immune ResponseTh17 Cytokines in Innate and Adaptive Immune ResponsesHematopoietic Growth FactorsCytokine and Anticytokine TherapiesClinical Assays for Cytokines7 Complement SystemPathways of the Complement SystemSystem ControlsComplement Receptors and Their Biological RolesBiological Manifestations of Complement ActivationComplement and Disease StatesComplement DeficienciesLaboratory Detection of Complement AbnormalitiesSECTION II: Basic Immunologic Procedures8 Safety and Quality ManagementLaboratory HazardsQuality ManagementRegulatory IssuesQuality Management Systems9 Principles of Serological TestingBlood Specimen Preparation and MeasuringDilutions10 Precipitation and Agglutination ReactionsAntigen–Antibody BindingPrecipitation CurveMeasurement of Precipitation by Light ScatteringPassive Immunodiffusion TechniquesElectrophoretic TechniquesComparison of Precipitation TechniquesPrinciples of Agglutination ReactionsTypes of Agglutination ReactionsInstrumentationQuality Control and Quality Assurance11 Labeled ImmunoassaysFormats for Labeled AssaysHeterogeneous Versus Homogeneous AssaysRadioimmunoassayEnzyme ImmunoassaysFluorescent ImmunoassaysChemiluminescent Immunoassays12 Molecular Diagnostic TechniquesCharacteristics of Deoxyribonucleic Acid and Ribonucleic AcidMolecular AnalysisDNA Sequencing13 Flow Cytometry and Laboratory AutomationCell Flow CytometryImmunoassay AutomationSECTION III: Immune Disorders14 HypersensitivityType I HypersensitivityType II HypersensitivityType III HypersensitivityType IV Hypersensitivity15 AutoimmunityEtiology of Autoimmune DiseaseSystemic Autoimmune DiseasesOrgan-Specific Autoimmune Diseases16 Transplantation ImmunologyHistocompatibility SystemsAllorecognitionTransplant RejectionGraft-Versus-Host Disease (GVHD)Immunosuppressive AgentsClinical Histocompatibility Testing17 Tumor ImmunologyIntroduction to Tumor BiologyTumor AntigensClinically Relevant Tumor MarkersLaboratory Detection of TumorsInteractions Between the Immune System and TumorsImmunoediting and Tumor EscapeImmunotherapy18 Immunoproliferative DiseasesMalignant Transformation of Hematologic CellsClassification of Hematologic MalignanciesLeukemiasLymphomasPlasma Cell DyscrasiasRole of the Laboratory in Evaluating Immunoproliferative Diseases19 Immunodeficiency DiseasesClinical Effects of Primary ImmunodeficienciesThe Nine Categories of Primary ImmunodeficienciesLaboratory Evaluation of Immune DysfunctionSECTION IV: Serological and Molecular Diagnosis of Infectious Disease20 Serological and Molecular Detection of Bacterial InfectionsHuman–Microbe RelationshipsBacterial Virulence FactorsImmune Defenses Against Bacterial Infections and Mechanisms of EvasionLaboratory Detection and Diagnosis of Bacterial InfectionsGroup A Streptococci (Streptococcus Pyogenes)Helicobacter PyloriMycoplasma PneumoniaeRickettsial Infections21 Spirochete DiseasesSyphilisLyme DiseaseRelapsing Fever Group—Borrelia Miyamotoi22 Serological and Molecular Diagnosis of Parasitic and Fungal InfectionsParasitic ImmunologyFungal Immunology23 Serology and Molecular Detection of Viral InfectionsImmune Defenses Against Viral InfectionsViral Escape MechanismsLaboratory Testing for Viral InfectionsHepatitis VirusesHerpes Virus InfectionsOther Viral Infections24 Laboratory Diagnosis of HIV InfectionHIV TransmissionCharacteristics of HIVImmunologic ManifestationsClinical Symptoms of HIV InfectionTreatment and PreventionLaboratory Testing for HIV InfectionScreening and DiagnosisDisease MonitoringTesting of Infants Younger Than 18 Months25 Immunization and VaccinesVaccinesPassive ImmunizationAdoptive ImmunotherapyGlossaryReferencesAnswer KeyIndex